Apixaban Patient Views

Clopidogrel and apixaban. I was recommended aspirin too but can’t tolerate it. Please note these drugs come with significant risk so need to be prescribed by an experienced doctor. Do see the review of my experience on my profile if you’re interested.

I had HELP apheresis, hyperbaric oxygen and blood thinners to address microclots. Probably all helped to some extent but I think probably the blood thinners most, given that I got a significant step-wise improvement with each titration up in dose.

The patient took clopidogrel and apixaban (was recommended aspirin too to make it ‘triple therapy’ but can’t tolerate aspirin). Obviously these meds aren’t without risk and need an experienced doctor to prescribe.

Over a few months, these meds got the patient from mainly sofa bound to walking 3 km a day, and improved severe brain fog to more of a moderate cognitive fatigue. Unfortunately after a few months the patient relapsed and we now think that there’s something very inflammatory and /or autoimmune going on - but other people have maintained their progress from blood thinners, especially if they’re treated earlier in illness.

‘Triple Therapy’ and ‘Professor Resia Pretorius’ are good search terms if you want to google more about the science! 😊

Honestly, I don’t think Aspirin is enough. I had my blood tested for micro clots twice. First time in a clinical trial by Mount Sinai where I didn’t get the results for 18 months, and then again by a private doctor using the same technique. My microclots were severe & widespread. Prior to both tests I had been on aspirin for 2 years. I then went on Eliquist & Nattokinase/serrapeptase in addition to Aspirin under the direction of a doctor. My symptoms improved, but I am still disabled. I think covid did too much damage prior to starting the anticoagulants. I would only do it under a recommendation of a doctor due to the risk of bleeding.

I am being treated for the microclots. The initial protocol was clopidrogrel 75mg, aspirin 75mg (both once a day) and Eliquis 5mg twice a day. I’m in a small group that didn’t respond to that but have recently added sulodexide 25mg twice a day which has made a big enough difference that I could drop the clopidrogrel and Eliquis and continue just with aspirin and sulodexide. Oh and a proton pump inhibitor to protect your stomach from the aspirin. If you do decide to try aspirin or other blood thinners, be aware that you will initially feel a LOT worse - as the clots break up, they release inflammatory particles into the system. All the best!

Triple therapy is a combination of three blood thinners (Clopidogrel, Aspirin, and Apixaban)