MAO-I Inhibitor Patient Views

This has potential side effects and adverse reactions to some medications, including MAO inhibitors such as rasagiline. I'm so happy the individual found this works for them! I take rasagiline so it's out for me.

On day 3 of 1 pill of 25/100 x3 daily, most of my symptoms were largely gone. My tremor, balance, slowed movement and dystonia all improved by the end of the first week of taking C/L. It's 9 months later and I've added some slight involuntary movement in my left leg but otherwise the same as the first month of taking the drug (I also take Rasagiline and a low dose of Ripinirole ER).

I have taken rasagiline (Azilect or its generic form) for over a decade, without any problems. The price dropped when it went generic, and should drop further when manufacturers other than Teva (the original patent-holder) become available. I do not notice any strong effect from stopping or resuming rasagiline, but I stick with it because the clinical trials showed benefits, and I have not had any adverse effects.

What “negative stuff” have you read about rasagiline or Azilect, aside from it being expensive and having weak beneficial effects?

I initially started out with selegiline but it didn’t really help…and the dietary restrictions (which were exaggerated & mostly unnecessary) made me miserable. I think I lasted less than a month before switching to c/l.

No I have not but I have had all symptoms controlled by 1 mg of Azilect a day since starting in fall 2019 after being diagnosed at 57. I had a mild resting tremor, moderate balance issues especially when turning, short term memory, double and blurry vision. The vision issues are due to my left eye turning in, so I just wear reading glasses which help with the blurry vision and I wear my prescription glasses now when watching tv to prevent eye fatigue. Everything else was addressed within 3 months of starting Azilect. Just saw my Neurologist and he is impressed with my continued success on the treatment alone for now. So I am keeping myself as stress-free as possible and trying to find the right balance in life.

After my own PD diagnosis, I tried each of the following drugs: Azilect (mao-i), Artane (anticholinergic), and then Requip (dopamine agonist). Azliect did nothing, Artane helped with the tremor but had horrible side effects, and Requip slightly improved all my symptoms.

When I was finally prescribed Sinemet, I saw a huge improvement in the way that I moved.... I had been living with the symptoms for so long that I did not realize how slow/ rigid I had become. Sinemet also helped with my gait, improved dexterity in my hands, and made me feel more cognitively alert.

While Sinemet helped with my tremor, I found that taking Requip in conjunction with Sinemet was more effective than taking either drug alone. To this day, I still take both.

rasagiline did nothing, amantadine beside desvenlafaxine made me feel good for a while but wasn’t a solution i still suffered from depression

I started on Rasageline immediately after diagnosis but felt no improvement. But after months of battling the side effects of C/l I discussed with my MDS and we added selegeline. I definitely feel it has extended my on time which is all I really wanted. But yeah my Dr said most people feel it does nothing.

I been curious about the Eldepryl, I was put on it a couple months after Sinemet to not get side effects later in life but I keep hearing not good things about it, maybe I should take to my doctor about it?

Have been taking coming Upto 3 yrs, as far as I know not doing much.

5mg twice a day.

Have missed some days haven’t noticed any difference, my symptoms haven’t got drastically worse. Not taking any other meds currently.